Cincinnati, OH (Sports Network) - Ryan Ludwick homered and drove in four, helping the Reds down the Padres, 6-4, on Wednesday.

Ludwick belted a two-run homer in the first inning, knocked in the go-ahead run in the fifth and added insurance with an RBI single in the seventh.

Zack Cozart also hit a first-inning homer -- a leadoff shot -- for the Reds, who have taken two of three to start this four-game series and are a major league-best 16-3 since the All-Star break.

Bronson Arroyo (7-6) won his third straight start, allowing four runs on seven hits over six innings. He walked two and struck out one.

Jonathan Broxton, who was acquired from the Royals on Tuesday, tossed a 1-2-3 eighth in his Cincinnati debut and Aroldis Chapman worked around a two-out double in the ninth to lock down his 23rd save of the season.

Chase Headley had a first-inning, two-run homer for the Padres and later added an RBI single, which briefly put his team on top in the fourth.

Kip Wells (2-4) lasted 4 1/3 innings against his former team and was charged with five runs on five hits. He also singled and scored a run.

The Padres were coming off of a 15-11 July -- their first winning month of the season.

08/01 22:27:23 ET